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At baseline, age and the proportion of subjects with heart failure, prior ischemic heart disease, prior MI, prior stroke and who used insulin were higher in the CVOTs than in the pooled glycemic efficacy trials, while low-density lipoprotein (LDL)-cholesterol, estimated glomerular filtration rate (eGFR) and the proportion of current smokers were higher in the glycemic efficacy trials than in the CVOTs

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Gaussian16 [107] was employed for the MCSCF geometry optimization of the selected models