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(3) Multitargeted therapy: BBR-isoliquiritigenin (ISL) dual therapy attenuates adipose inflammation and dyslipidemia via IRS1-PI3K-Akt pathway activation in DIO mouse, while BBR-catechin-capsaicin polypharmacology outperforms monotherapies in 3T3-L1 adipocytes [181, 195]
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These types of models are commonly used to investigate how signaling molecules influence coordinated repair responses rather than isolated cellular processes
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