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Rapamycin analogs reduce mTORC2 signaling and inhibit AKT activation in AML

Foundational supportsremoval of ongoing exposure, digestive stability, bile flow, hydration, sleep, and nervous system regulationmust precede targeted detoxification strategies

Caffeine: Caffeine is known to stimulate gastric emptying and may exacerbate gastrointestinal side effects associated with GLP-1 medications, such as nausea or diarrhea

This framework generates testable predictions and potential monitoring endpointsincluding lean mass trajectory, micronutrient status, fat-soluble vitamin surveillance, and exploratory redox-related biomarkersthat can be evaluated in future longitudinal and interventional studies