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Hypersecretion of gastric inhibitory polypeptide following oral glucose in diabetes mellitus
However, they often improve after a few weeks
So if you have agents that are able to both be safe from a cardiovascular perspective, and perhaps even reduce further events, and also lower weight substantially, that has the ability to lower the risk of multiple other complications that patients with cardiovascular disease are now suffering from, such as diabetes, chronic kidney disease, possibly heart failure, osteoarthritis, and fatty liver disease. He noted that a definitive answer on whether tirzepatide will reduce CV events like semaglutide did in SELECT will come from ongoing large trials like SURPASS-CVOT and SURMOUNT-MMO
7 GI side effects are not only major contributors to stopping GLP-RAs, but are more likely to be reported as such by patients than by their physicians
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