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Interest in these medications has recently accelerated, although access to and use of GLP-1 RA medications may be impacted by high cost, limited insurance coverage for patients without T2D, and medication shortages

While cross-trial comparisons are limited by differences in patient populations and study duration, the head-to-head percentage is clear: Retatrutides triple-action mechanism has generated the highest average weight loss percentage reported to date for any single pharmacological agent

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