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In countries like Turkey, where medical aesthetics are highly advanced and affordable, glutathione-based skin whitening treatments attract international patients seeking safe, medically supervised solutions

Presented for research literature review only Meister A (1995)

As with all supplements, some people should avoid milk thistle altogether, primarily individuals who are allergic or sensitive to Asteraceae and/or Compositae plants and those currently on medications that may severely interact with silymarin (e.g., deferiprone or simeprevir)

It most commonly affects the central facial skin on the nose, cheeks, and forehead