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Variants in the GLP1R gene (including the R131Q and P60A variants) have been associated with differential weight loss responses, gastrointestinal tolerability, and HbA1c changes in patients treated with semaglutide and liraglutide
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The study found reversal of MASH without worsening of fibrosis of about 25% in the 80-milligram group and about 30% in the 100-milligram group versus about 10% in the placebo group at 52 weeks
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