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Recent trials have shown: Up to 20% body weight reduction with weekly GLP-1 agonists (Wilding et al., NEJM) Improvements in HbA1c, fasting glucose, and cardiovascular outcomes (Marso et al., NEJM) This drug class is now widely used for: Obesity (with or without diabetes) Type 2 diabetes PCOS-related insulin resistance Metabolic syndrome Common Side Effects and Patient Concerns Despite their benefits, GLP-1 agonists are not without risks or drawbacks
Elevated plasma TMAO concentrations were observed in mice exposed to 2% sodium chloride (NaCl) for a period of two weeks, and these concentrations were correlated was decreased urinary excretion of TMAO (107)
P = 0.0026, with upper to lower ratio increasing from 0.89 to 2.77), indicating a more active protein 14 , an increase in mitofusin 2 (ca
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