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Structural features molecular size, charge, susceptibility to specific enzymes such as DPP-4, and plasma-protein binding explain why one peptide lasts 2 minutes and another lasts a week
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Despite the absence of a prolonged anorectic effect, Cagrilintide produced a sustained and significant reduction in body weight in WT mice by 3.4 g after 21 days, while no such effect was observed in KO animals
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