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Lentiviral infection For lentiviral packaging, HEK293FT cells (#R70007, Invitrogen) were cultured in DMEM medium supplemented with 10% FBS and penicillin/streptomycin

10.3389/fcell.2021.690079 72 LiY.NourbakhshN.PhamH.ThamR.ZuckermanJ

Lowering GSH levels also triggers ferroptosis through deactivation of GPX4, leading to accumulation of lipid peroxides [87] In some cases, GSH depletion alone can induce therapeutic effects without relying on Fenton chemistry, which typically involves HO reacting with Fe 2 to form hydroxyl radicals (OH) that damage critical biomolecules such as DNA, proteins, and lipids

In fact, MPTP depletes kynurenic acid level (77)