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Monitoring recommendations for safe use: Baseline assessment including mental health history and current medications Gradual dose titration over five weeks to minimise adverse effects Regular follow-up appointments, particularly during the first three months Discontinuation if less than 5% weight loss after 12 weeks on the 3.0 mg dose Patient education about symptoms requiring medical attention Patients should be advised to contact their GP or prescribing clinician if they experience any concerning symptoms

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People on the higher dose of oral semaglutide lost less 11.5 pounds on average, or a little more than 5 percent of their starting weight