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33.4 pM for GIP) but approximately 13-fold weaker potency than GLP-1 in activating GLP-1R (EC50 = 934 pM for tirzepatide vs.70.5 pM for GLP-1)
These weight loss medications are an excellent option for individuals seeking a different approach to weight loss, as they are highly effective when used in conjunction with a balanced diet and regular exercise
Tirzepatide activates both GLP-1 and GIP receptors this dual mechanism produces stronger effects on insulin sensitivity and consistently greater weight loss in clinical trials
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