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NSAIDs, such as aspirin, inhibit cyclooxygenase (COX) activity, reducing prostaglandin synthesis, directly suppressing neutrophil function, and effectively controlling acute inflammation, although concerns about their safety persist (227)

Most frequently cited research concerns inflammatory signalling in cell systems and experimental colitis models

Important unresolved questions include long-term toxicology, interaction effects, endocrine and metabolic safety, formulation consistency, validated potency methods, independent replication, and whether adequately powered controlled studies would support broader conclusions

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