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According to the safety communication, patients at particular risk for developing Torsade include: Patients with underlying heart conditions, such as congenital long QT syndrome Patient who are predisposed to low levels of potassium and magnesium in the blood Patients taking other medications that lead to QT prolongation Clinical Studies: Zofrans Link to Heart Rhythm Problems The FDA released another Drug Safety Communication in June 2012, informing health care professionals and the public that preliminary results from a clinical study suggested that a 32 mg, single intravenous dose of Zofran may cause QT interval prolongation

You may plateau faster than with guideline doses

This could be temporary because of swelling or a long-term problem that needs surgery to fix

The Room Temp Debacle: Leaving a vialeither lyophilized or, even worse, reconstitutedout on a lab bench for hours or a weekend is a death sentence for the peptide