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How GLP-1 Drugs Cause It: Slowing effect extends beyond the stomach Affects small intestine and colon Food or stool becomes stuck Can be life-threatening without treatment Symptoms: Severe abdominal pain and cramping Inability to pass gas or stool Severe bloating and distention Vomiting (may include fecal material) Loss of appetite Treatment: Often requires emergency hospitalization Nasogastric tube to decompress the stomach IV fluids and electrolytes Some cases require emergency surgery Risk of intestinal perforation or death if untreated Legal Claims: Patients who experienced bowel obstruction or ileus argue: This serious complication was not adequately disclosed Emergency room visits and surgeries could have been prevented Permanent bowel damage occurred Lost wages and medical bills are substantial Learn more about ileus warning signs and symptoms
It is freely soluble in water, hot alcohol, and practically insoluble in acetone, ether and benzene
What they did: Obese mice received AOD-9604 orally (via gavage) for 14 days at various doses (50, 250, 500 g/kg)
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