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TB-500 upregulates vascular endothelial growth factor (VEGF) and related pro-angiogenic factors, promoting new blood vessel formation crucial to tissue repair
The clinic is sparkling clean too
The increased population of CD8 + T cells in adipose tissue is hypothesized to promote and maintain the pro-inflammatory M1 phenotype of ATMs with age [94, 102]
In the Phase 2 obesity trial it produced about 24% weight loss at 12 mg over 48 weeks, the most of any drug in the class, and it cut liver fat by 86% in the people who started with fatty liver. In the 80-week Phase 3 obesity trial of 2,300 adults with an average BMI of 40, 12 mg produced 28% weight loss and 9 mg reached 26%
