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Where positive effects have been observed, the magnitude of weight loss is typically smallgenerally in the range of 0.5-2 kgwhich may not be clinically meaningful for most individuals seeking weight management
Lyophilized powder is more stable because removing water eliminates the aqueous environment where oxidation occurs most readily
TH potentiates the production of non-12-OH FXR-antagonistic BAs Recent evidence suggests that a couple of non-12-OH BAs, including T(/)MCA, (T/G)UDCA, and (T)HDCA, can exert FXR-antagonistic effects 4,9,10,29 , while intestinal FXR inhibition is able to stimulate GLP-1 production and secretion in L cell 11
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