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Avoid administration immediately after meals, particularly high-carbohydrate meals

Geerling BJ, Badart-Smook A, Stockbrgger RW, Brummer RJ

They slow gastric emptying, promoting feelings of fullness and reducing food intake

Important associated symptoms include: Numbness, tingling, burning, or reduced sensation Muscle cramps, stiffness, pain, or spasms Visible muscle thinning or wasting Fatigue that worsens with repeated use of a muscle Changes in speech, chewing, swallowing, breathing, or facial expression Back or neck pain radiating into an arm or leg Patients often describe symptoms using everyday language, and that is helpful