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doi: 10.1016/j.cmet.2022.07.013
The medication does the pharmacological work while the person (with Sunnysides help) builds new patterns around it
The mechanisms behind this upregulation appear to involve: Activation of the Nrf2 pathway, which controls the expression of various antioxidant enzymes including GR Modulation of cellular signaling cascades that respond to redox status Alteration of mitochondrial metabolism, influencing NADPH availability for GR activity Reduction of inflammatory signaling that can suppress antioxidant enzyme expression These effects suggest that hydrogen water may provide a "hormetic" stimulusa mild oxidative challenge that triggers beneficial adaptive responses in cellular antioxidant systems
GST is polymorphic and three polymorphisms decrease or abolish GST activity, although it is unclear whether possession of these polymorphisms leads to an increased propensity for paracetamol toxicity [41]
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