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Wearable chemical sensors for biomarker discovery in the omics era
The hemoglobin fractionation assay confirmed that E64d-treated parasites have significantly decreased heme and hemozoin levels, while undigested hemoglobin levels were elevated following treatment (Supp Fig 2A)
Intriguingly, the decrease in dTTP pools through SHMT2 knockdown was insufficient to change the speed of DNA replication fork progression and JMF4073 sensitivity in T315I-Bcr-Abl-32D cells (Fig
This selectivity is the defining feature of AOD 9604
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