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Notably, no significant increases in markers of inflammation or oxidative stress were observed in the liver of Gclc L-KO mice compared to Gclc WT mice (Fig

Inflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis

It is possible that, in addition to factors such as reduced alcohol consumption, weight loss-related improvements in body image, or relief associated with better glycaemic control in diabetes, there may also be direct neurobiological mechanisms involved for example, through changes in the functioning of the brains reward system, says Research Director, Docent Markku Lhteenvuo from the University of Eastern Finland