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Although the natriuretic effect of SGLT-2i appears small and transient [46], at least in carefully controlled studies, it is plausible that the modulation of the preload emerges in interaction with individual characteristics (background therapy, dietary sodium intake, pre-edematous status) and/or under circumstances that make it more clinically relevant like in the postabsorptive state
Zalewska et al
PAF, platelet-activating factor
The decision often depends on the specific research goals and the individual immune profile being studied
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