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DPP4 inhibitors have a very minimal effect on endogenous incretins (GLP-1, GIP) Dual GLP-1/GIP agonists (Tirzepatide) possess the properties of both incretins and are associated with more significant weight loss than GLP-1 agonist monotherapy

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For the oGTT, body weights were recorded and at the start of the experiment mice were given 2 g kg 1 of glucose (100 mg ml - 1 ) by oral gavage, and blood glucose was monitored at 0, 15, 30, 60, 90, and 120 min using an Accu-Chek Guide glucometer from tail blood

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