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The meta-analysis by Chen et al
You will also hear guidance from iFIT trainer John Peel, who created a strength program designed specifically to help people maintain muscle during weight loss
One of the possible reasons for this is that metformin inhibits sodium-glucose cotransporter1 (SGLT1) on small intestinal epithelial cells, decreasing the intra- and extracellular Na + concentration gradient, thereby inhibiting intestinal glucose absorption and increasing glucose utilization (Lenzen et al., 1996
This can lead to better endurance, reduced fatigue, and more efficient training sessions when combined with proper nutrition and exercise
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