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118,119 Temporary disruption of BBB has been widely studied as a prevalent approach for delivering drugs into the CNS from the circulatory system
Within safe limits, yes
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Their common structural characteristic is a RING-type ubiquitin ligase domain and the presence of tandemly repeated SUMO interaction motifs (SIMs) enabling them to specifically target and ubiquitinate polySUMOylated substrates 1820
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