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Over recent years two trials with nerve growth factor (NGF) designed to protect forebrain cholinergic neurons (early to moderate stage AD patients) were terminated after phase I [15,16] (NCT00017940, NCT00876863)

A novel controlled metabolic accelerator for the treatment of obesity-related heart failure with preserved ejection fraction: rationale and design of the phase 2a HuMAIN trial

Given that waist circumference independently predicts cardiovascular events beyond BMI alone, this specific measurement carries clinical significance

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