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In parallel, microarray data generated by Steiner et al., who isolated mantle cells after having used copper to lesion hair cells, showed a complicated damage response consisting of upregulation of a subset of the Wnt pathway components and target genes ( Wnt3 , Wnt7a , Wnt9a ) but downregulation of others ( Wnt9a , Axin2 , Tcf4 , Sfrp2 ) immediately after damage (Steiner et al., 2014)