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Injections are particularly appropriate for those with: Pernicious anaemia, an autoimmune condition affecting B12 absorption Conditions affecting the stomach or small intestine, such as Crohns disease or coeliac disease Those who have had gastric surgery or bariatric procedures Strict vegans and vegetarians not meeting their B12 needs through food or oral supplements For those who can absorb B12 normally, oral supplements are generally an effective and well-evidenced alternative to injections
However, for most people, the practical benefits of morning absorption on an empty stomach outweigh the benefits of nighttime dosing
Anyone undergoing chemotherapy or taking anti-psychotic medications must seek medical guidance first
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