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The key insulinotropic actions of GLP-1 via the class B1 G-protein-coupled receptor (GPCR) are exerted by cyclic adenosine monophosphate (cAMP) formation, which, in conjunction with increased Ca 2+ levels, promotes exocytosis of insulin-containing vesicles [39]
Martin HL, Teismann P
Notably, SQOR deficiency leads to reduced cellular ubiquinol (CoQ 10 H 2 ) levels and increased sensitivity to ferroptotic stress, positioning SQOR as another mitochondria-resident suppressor of ferroptosis
Conclusions and Future Perspectives The collective evidence positions incretin receptor agonists as a unique class of drugs with multi-organ anti-fibrotic potential, now extending to fibro-inflammatory diseases like osteoarthritis
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