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It has a neuroendocrine pathway independent of the GLP-1 receptors, working by stimulating melanocortin-4 receptors (MC4R) to reduce hunger and increase basal metabolic rate

Real-World Experiences of Semaglutide in Type 2 Diabetes: A Case Series. Journal of Clinical Case Reports, 10(2), 1203

KadowakiTIsendahlJKhalidULeeSYNishidaTOgawaWet alSemaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an East Asian population (STEP 6): a randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial