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Participants had a longstanding history of diabetes (14.5 9.6 years) and a mean baseline BMI of 31.1 5.3 kg/m 2
When tissues such as muscle, liver, and fat no longer respond effectively to insulin, glucose remains in the bloodstream, increasing the risk of type 2 diabetes, obesity, and cardiovascular disease. This connection between estrogen and insulin resistance has sparked interest in how hormone replacement therapy (HRT) may work synergistically with modern weight loss therapies, particularly glucagon-like GLP-1 receptor agonists and glucose-dependent insulin tropic polypeptide (GIP) receptor/GLP-1 receptor agonist combos
Vitamin C transport and its role in the central nervous system
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