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Under physiological conditions, pigmentation can protect the skin against harmful UV injury
In atherosclerotic disease, GLP-1RAs have been shown to attenuate and stabilize development of atherosclerotic plaques through anti-inflammatory mechanisms (inhibition of IL-6 and TNF-, and NF-B), inhibit activation and recruitment of macrophages and prevent vascular remodeling
While large human trials are pending, preclinical and mechanistic evidence is strong
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