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Pathogen eradication with antibiotics became the norm and dominated 20th-century medicine along with a focus on psychopharmacology as chemical imbalance-based theories of depression gained ground in the 1950s and 1960s.12 During this time, Ren Dubos, PhD, and other highly respected microbiologists again proposed that the noxious components produced by intestinal flora impacted ones physical and mental well-being

Current Rheumatology Reports, 10 (2), 110

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Subsequent cohorts were dosed after the dosing regimen in the preceding cohort was recommended to be safe and well tolerated based on the safety and laboratory data through at least day 15