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I personally usually advise people to stick to RDA level vitamins and if they want to go higher with B6 (based on labs), to stay under 10mg which I still think is a reasonable level of caution considering all the evidence
In these cases, we may suggest B12 shots to help prevent or reverse a deficiency
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Surgical procedures or conditions that affect the gut, such as gastric bypass surgery or celiac disease, can prevent intrinsic factors from binding to B12 and prevent the body from breaking it down before absorbing the vitamin
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