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The differences in the structure between liraglutide and semaglutide were the Ala to Aib substitution in position 8, a longer linker (Glu-2xOEG vs Glu), and an increase in the length of the fatty diacid chain from C16 to C18

Inhibition of the glutamate forming enzyme glutamate carboxypeptidase II (GCP II), may help prevent both peripheral and central nervous system damage during chemotherapy and has been proposed as a possible treatment for amyotrophic lateral sclerosis (ALS), stroke, and even Multiple Sclerosis plus other neuropsychiatric diseases (Rahn et al, 2012)

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