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Current treatment remains centered on lifestyle intervention, while approved and emerging pharmacologic options such as resmetirom and semaglutide offer important advances but are limited by restricted indications, adverse effects, and incomplete coverage of the metabolic, inflammatory, and fibrotic pathways that drive disease progression
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Dialysate composition must be tailored if any GLP-1 is used
Lactate produced during glycolysis can increase the cell-surface expression of the phagocytic receptors MerTK and LRP1 in a calcium-dependent manner, thereby promoting sustained uptake of apoptotic cells (Schilperoort et al., 2023a) (Figure 2B)
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