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Meta-analyses show statistically significant but clinically modest reductions in body weight with L-carnitine supplementation, particularly in older adults and those with obesity or metabolic conditions
An earlier 12-week trial in 300 obese adults produced a genuine positive signal the 1 mg daily dosing arm showed a statistically significant 2.8 kg mean weight loss versus 0.8 kg in the placebo group and that result is what justified moving into the larger Phase IIb trial
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