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In the UK, NHS access is restricted under NICE TA875, typically via specialist weight management services and with higher BMI thresholds
Tirzepatide vs semaglutide Tirzepatide adds GIP receptor activation on top of GLP-1, producing higher average weight loss than semaglutide (22.5% vs 14.9% at peak doses)
Semaglutide, administered once weekly at dosages ranging from 0.5 to 1 mg, showed superior efficacy compared to Dulaglutide, dosed once weekly from 0.75 to 1.5 mg, reducing both HbA1c and FBS levels
Kidney problems, including possible kidney failure
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