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GLP-1s arent just targeting the brain, like many older medications, said Carolina Haass-Koffler , associate professor of psychiatry, human behavior and of behavioral and social sciences at Brown

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It may also lead to more serious side effects

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Patients on orforglipron should be aware of gallstone symptoms (right upper quadrant pain, nausea after fatty meals) and report them promptly

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A bright future for GLP-1 pills There is a fast-growing bank of evidence that GLP-1s have benefits beyond weight loss, but these two studies demonstrate that the pills are likely to change the landscape even further

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