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The DPP-4 inhibitors sitagliptin, alogliptin and saxagliptin have demonstrated cardiovascular safety in clinical trials involving patients at a high cardiovascular risk.3638 In the SAVOR-TIMI 5 study, saxagliptin was associated with a significant increase in hospital admission due to heart failure,38 a situation not observed with the other molecules
When to Stop and Call a Doctor Stop taking the medication and seek medical guidance if you develop chest pain, fainting, severe abdominal pain, ongoing vomiting, signs of dehydration, yellowing skin or eyes, a severe allergic reaction, rapid heartbeat, confusion, or major mood changes
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