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Notably, the combination of (-)-Vestitol and Salviolone synergistically affected cognitive function in APP/PS1 transgenic mice by reducing A deposition and lowering toxic soluble A levels in the brain
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This step has 5-hydroxy-L-tryptophan as substrate, pyridoxal 5-phosphate as an optional activator, and is influenced by Al 3+ , Zn 2+ , Ca 2+ , and Mg 2+ levels
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