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Therefore, activating GLP-1R in fibroblasts could antagonize macrophage-derived signal-triggered fibroblast activation by inhibiting NLRP3 inflammasome activation, PFKFB3-driven glycolysis and histone lactylation

By integrating biological, psychological, and experiential dimensions, future strategies can move toward more personalized, durable, and patient-centered obesity care

How to Preserve Muscle While Taking GLP-1 Weight-Loss Drugs GLP-1 medications can cause significant muscle loss alongside fat loss

GLP-1RAs might have a direct impact on keratinocytes, as evidenced by the detection of GLP-1R and glucagon in neonatal mouse skin and cultured skin cells [203]