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Maackiain promotes NRF2 activation through the PKC signaling pathway, preventing A-induced oxidative stress and cellular damage in PC12 cells, indicating its potential for treating AD [48]
Current therapeutic approaches aim to modulate these pathways, including direct Nrf2 activation and glial-targeted interventions, although significant challenges persist in delivering antioxidant agents across the BBB and in validating neuroprotection markers
Based on findings from the CRND8 mouse model, in which amyloid deposits are associated with neuropathological changes, it is conceivable that similar mechanisms, potentially involving the accumulation of metal ions such as copper, iron, or zinc, could also occur within amyloid plaques in human patients [193, 194]
Behavioral weight loss interventions to prevent obesity-related morbidity and mortality in adults: US preventive services task force recommendation statement
