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In a 68-week clinical trial, patients treated with GLP-1 experienced an average weight loss of 14.9% from their initial body Trusted Source Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial Rubino D, Abrahamsson N, Davies M, et al Go to Source weight
The rate of loss typically slows compared to weeks 1-6 (the easy water weight is long gone by this point), but it becomes more consistent, usually 1 to 2 pounds per week rather than the stop-start pattern of the early phase
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