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In the SURMOUNT-1 trial, participants on the highest dose of tirzepatide lost an average of 22.5 percent of their body weight at 72 weeks (Jastreboff et al., NEJM , 2022), compared to roughly 15 percent with semaglutide 2.4 mg in the STEP 1 trial (Wilding et al., NEJM , 2021)
Some researchers run 12 weeks on / 4 weeks off for more aggressive anti-aging protocols
For readers primarily interested in hair applications, topical is the evidence-supported route
Some of them experience diarrhea, and others are forced to deal with constipation
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