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The viscosity of the ER increases during ferroptosis, possibly due to aggregation of polyunsaturated fatty acids (PUFAs) and phospholipids, leading to hardening of the ER (Liu et al
Thus, not only the size but also the charge and shape of the glutathionylated substrate are relevant with GS in GSSG being the optimal leaving group in accordance with a 2nd glutathione-interaction site (Fig
Publications Journal Impact Factor Most Recent Nat Cell Biol2024 Sep;26(9):1545-1557
doi: 10.3390/antiox9080705 164 ZhouFHuangLQuSLChaoRYangCJiangZSet al
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