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General pathological changes, such as impaired blood supply and biomechanical alterations, are key contributors to the disease process

While GLP-1R expression in the GI tract is classically ascribed to the myenteric plexus, the highest level of GLP-1R expression in the gut is in the Brunner's glands in the upper duodenum (87)

[4] Clinical assessment should focus on identifying the cause of elevated levels rather than assuming toxicity from supplementation alone

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