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In most cases, a simple and repeatable system is easier to maintain long-term, especially as appetite and eating patterns continue to change on GLP-1 medications
This translated to ~15 kg weight loss in treated patients a magnitude approaching bariatric surgery in some cases
Metformin has been shown to have some anti-inflammatory effects in clinical studies in patients with T2DM, in experimental studies in rodent models of obesity and T2DM, and in vitro experiments with several immune cells (Foretz et al., 2019
You can learn more about this approach in Why Bioavailability Matters
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