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While migraine diagnosis currently relies on clinical criteria, validation of these findings in independent cohorts is essential before any clinical application can be considered [46]
The risk of hypoglycemia with GLP-1/GIP agonists is generally low unless combined with insulin or insulin secretagogues (sulfonylureas), which may require dose adjustment of those medications
Impaired glutamate uptake leads to extracellular accumulation, triggering the overactivation of AMPA and NMDA receptors and driving neuronal hyperexcitability
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