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TGR5-mediated stimulation of GLP-1 secretion was dependent on cAMP formation and was blocked by inhibitors of adenylyl cyclase (Katsuma et al., 2012)

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As hypothesized, while financial barriers were the most common reason for discontinuation at all time points, patients discontinuing due to cost were more likely to do so later in treatment, whereas those discontinuing due to side effects tended to do so earlier

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